Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.40 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.39 |
| ▸ | ANPEP | P15144 | 2/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953652 | 1.00 | ACE (0.47) | ACEHDAC4HDAC7HDAC5NOTUM | |
| SCHEMBL19960636 | 0.83 | HDAC4 (0.43) | HDAC4HDAC7HDAC5NOTUMSRD5A1 | |
| SCHEMBL19960827 | 0.81 | ANPEP (0.40) | ACEHDAC4HDAC7HDAC5NOTUM | |
| SCHEMBL19953701 | 0.80 | ACE (0.47) | ACEHDAC4HDAC7HDAC5NOTUM | |
| SCHEMBL19960826 | 0.80 | ACE (0.47) | ACEHDAC4HDAC7HDAC5NOTUM | |
| SCHEMBL19953646 | 0.80 | ACE (0.47) | ACEHDAC4HDAC7HDAC5NOTUM | |
| SCHEMBL19953669 | 0.80 | MEN1 (0.42) | NOTUMHPGD | |
| SCHEMBL19953636 | 0.79 | FABP5 (0.44) | HDAC4HDAC7HDAC5GRM7 | |
| SCHEMBL19953670 | 0.78 | ACE (0.42) | ACEGRM7 | |
| SCHEMBL14987797 | 0.76 | SRD5A1 (0.44) | HDAC4HDAC7HDAC5NOTUMSRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |