Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | GRM7 | Q14831 | 5/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953510 | 0.84 | HRH3 (0.46) | FABP5MTNR1AMTNR1BMAPTGRM7 | |
| SCHEMBL19953664 | 0.84 | HRH3 (0.46) | FABP5MTNR1AMTNR1BMAPTGRM7 | |
| SCHEMBL19953768 | 0.81 | TSHR (0.50) | FABP5MAPTGRM7HRH3GAA | |
| SCHEMBL19953513 | 0.79 | GRM7 (0.62) | FABP5MTNR1AMTNR1BMAPTGRM7 | |
| SCHEMBL19953654 | 0.79 | GRM7 (0.62) | FABP5MTNR1AMTNR1BMAPTGRM7 | |
| SCHEMBL19953505 | 0.79 | HRH3 (0.43) | MAPTGRM7HRH3GAATSHR | |
| SCHEMBL19953652 | 0.79 | ACE (0.47) | HDAC4HDAC7HDAC5GRM7 | |
| SCHEMBL19953522 | 0.79 | ACE (0.47) | HDAC4HDAC7HDAC5GRM7 | |
| SCHEMBL19960636 | 0.78 | HDAC4 (0.43) | MTNR1AMTNR1BHDAC4HDAC7HDAC5 | |
| SCHEMBL19960682 | 0.75 | GRM7 (0.43) | MAPTGRM7TSHRLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | claimed |
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |