SCHEMBL19953534

SCHEMBL19953534

O=C[C@H](Cl)N1CCc2ccccc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 3/20 0.42
KMT2A Q03164 3/20 0.42
ALDH1A1 P00352 2/20 0.42
USP2 O75604 1/20 0.42
CDK4 P11802 1/20 0.42
ALOX15 P16050 1/20 0.42
CCND1 P24385 1/20 0.42
NOTUM Q6P988 1/20 0.41
GAA P10253 4/20 0.41
TP53 P04637 3/20 0.41
MAPT P10636 3/20 0.41
TSHR P16473 1/20 0.40
SLC6A2 P23975 2/20 0.40
SLC6A4 P31645 2/20 0.40
NPC1 O15118 1/20 0.40
PKM P14618 1/20 0.40
NFKB1 P19838 1/20 0.40
RAB9A P51151 1/20 0.40
NFKB2 Q00653 1/20 0.40
RELA Q04206 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4795868 0.90 SMN1; SMN2 (0.46) MEN1KMT2AALDH1A1NOTUMMAPT
SCHEMBL28292829 0.80 ALDH1A1 (0.48) MEN1KMT2AALDH1A1USP2CDK4
SCHEMBL25333374 0.79 SLC6A2 (0.43) MEN1KMT2AALDH1A1USP2CDK4
SCHEMBL27463313 0.79 ALDH1A1 (0.42) MEN1KMT2AALDH1A1USP2CDK4
SCHEMBL27675115 0.79 NOTUM (0.45) MEN1KMT2AALDH1A1USP2CDK4
SCHEMBL23529755 0.78 SLC22A12 (0.42) MEN1KMT2ANOTUMMAPTNPC1
SCHEMBL28292118 0.77 MAPT (0.48) MEN1KMT2AALDH1A1USP2CDK4
SCHEMBL14060360 0.77 ALDH1A1 (0.46) MEN1KMT2AALDH1A1USP2CDK4
SCHEMBL23723712 0.76 SLC6A2 (0.46) MEN1KMT2AALDH1A1USP2CDK4
SCHEMBL307372 0.76 NOTUM (0.45) MEN1KMT2AALDH1A1NOTUMGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025090871-A1 ELECTROPHILIC PURINE COMPOUNDS FOR MODIFICATION OF PROTEINS UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) 2025-05-01 WO disclosed
WO-2018144869-A1 COMPOSITONS AND METHODS FOR MODULATING UBA5 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-08-09 WO disclosed
WO-2018144871-A1 COMPOSITIONS AND METHODS FOR MODULATING PPP2R1A THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2018-08-09 WO disclosed
WO-2018047983-A1 INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2018-03-15 WO disclosed