Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 2/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.44 |
| ▸ | F11 | P03951 | 1/20 | 0.43 |
| ▸ | HHAT | Q5VTY9 | 2/20 | 0.41 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | CASP2 | P42575 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19960671 | 0.86 | HRH3 (0.47) | ACEMTNR1BMTNR1AF11HRH3 | |
| SCHEMBL19953782 | 0.86 | F11 (0.55) | ACEMTNR1BMTNR1AFABP5F11 | |
| SCHEMBL19960670 | 0.83 | GHSR (0.49) | MTNR1BMTNR1AFABP5 | |
| SCHEMBL19953699 | 0.82 | ACE (0.46) | ACEMTNR1BMTNR1AFABP5F11 | |
| SCHEMBL16111164 | 0.80 | ACE (0.68) | ACEMTNR1BHHAT | |
| SCHEMBL19953578 | 0.79 | ACE (0.41) | ACEMTNR1BF11HHATCYP2D6 | |
| SCHEMBL19953576 | 0.79 | ACE (0.41) | ACEMTNR1BF11HHATCYP2D6 | |
| SCHEMBL19953575 | 0.79 | ACE (0.41) | ACEMTNR1BF11HHATCYP2D6 | |
| SCHEMBL19960664 | 0.78 | HDAC8 (0.43) | ACEMTNR1BMTNR1AF11HDAC8 | |
| SCHEMBL19960847 | 0.78 | EPHX2 (0.43) | ACEMTNR1BMTNR1AFABP5CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |