Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.52 |
| ▸ | VCP | P55072 | 3/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 4/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 4/20 | 0.41 |
| ▸ | PRMT8 | Q9NR22 | 2/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25568889 | 0.94 | RAD52 (0.50) | RAD52VCPCARM1PRMT6PRMT8 | |
| SCHEMBL21549043 | 0.90 | RAD52 (0.66) | RAD52VCPCARM1PRMT6PRMT8 | |
| SCHEMBL24204306 | 0.84 | ACE2 (0.44) | RAD52VCPCARM1PRMT6PRMT8 | |
| SCHEMBL3605906 | 0.83 | RAD52 (0.53) | RAD52VCPCARM1PRMT6PRMT8 | |
| SCHEMBL12838201 | 0.82 | RAD52 (0.60) | RAD52VCPCARM1PRMT6PRMT8 | |
| Hydrochloric Acid SCHEMBL3598388 | 0.82 | RAD52 (0.51) | RAD52VCPCARM1PRMT6PRMT8 | |
| SCHEMBL24333102 | 0.80 | RAD52 (0.59) | RAD52CARM1PRMT6PRMT8PRMT1 | |
| SCHEMBL4281737 | 0.80 | RAD52 (0.63) | RAD52VCPCARM1PRMT6PRMT8 | |
| SCHEMBL24204664 | 0.79 | MEN1 (0.47) | RAD52CARM1PRMT6MEN1MITF | |
| SCHEMBL22123351 | 0.77 | RAD52 (0.82) | RAD52VCPCARM1PRMT6PRMT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3003301-B1 | NOVEL SUICIDAL LSD1 INHIBITORS TARGETING SOX2-EXPRESSING CANCER CELLS | BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIV OF NEVADA LAS VEGAS (US) | 2021-02-24 | — | — | EP | disclosed |
| EP-3509627-A1 | LYSINE SPECIFIC HISTONE DEMETHYLASE-1 INHIBITORS AND USES THEREFOR | University of Canberra (AU) | 2019-07-17 | — | — | EP | disclosed |
| WO-2018045422-A1 | LYSINE SPECIFIC HISTONE DEMETHYLASE-1 INHIBITORS AND USES THEREFOR | UNIVERSITY OF CANBERRA (AU) | 2018-03-15 | — | — | WO | disclosed |