Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | TNF | P01375 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 2/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12853767 | 0.84 | DRD2 (0.47) | DRD2DPP4DPP9DPP7SIGMAR1 | |
| SCHEMBL19954041 | 0.81 | OPRD1 (0.36) | OPRM1 | |
| SCHEMBL15247408 | 0.77 | DRD2 (0.53) | DRD2SIGMAR1OPRM1 | |
| SCHEMBL15247409 | 0.76 | DRD2 (0.40) | DRD2DPP4DPP9DPP7SIGMAR1 | |
| SCHEMBL30047438 | 0.75 | CRBN (0.57) | OPRM1 | |
| SCHEMBL5463091 | 0.70 | KCNH2 (0.47) | DRD2SIGMAR1 | |
| SCHEMBL12853726 | 0.69 | OPRD1 (0.38) | OPRM1 | |
| SCHEMBL4472985 | 0.69 | DRD2 (0.66) | DRD2SIGMAR1MAPKAPK2OPRM1 | |
| SCHEMBL2271090 | 0.68 | DRD2 (0.55) | DRD2SIGMAR1OPRM1 | |
| SCHEMBL654759 | 0.68 | DRD2 (0.65) | DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914719-B2 | Hydroxybenzamide derivatives and their use as inhibitors of HSP90 | ASTEX THERAPEUTICS LTD. (GB) | 2018-03-13 | — | — | US | disclosed |