Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.49 |
| ▸ | MEP1B | Q16820 | 4/20 | 0.46 |
| ▸ | ANO1 | Q5XXA6 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.41 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17790246 | 0.85 | ROCK2 (0.52) | ROCK2ROCK1ANO1KMT2AGAA | |
| SCHEMBL18901186 | 0.84 | ROCK2 (0.51) | ROCK2ROCK1ANO1KMT2AGAA | |
| SCHEMBL19954190 | 0.81 | MEP1B (0.51) | ROCK2ROCK1MEP1BKMT2AGAA | |
| SCHEMBL18901187 | 0.81 | LOXL2 (0.55) | ROCK2ROCK1ANO1KMT2AGAA | |
| SCHEMBL18901189 | 0.81 | ROCK2 (0.48) | ROCK2ROCK1ANO1MMP13SPHK2 | |
| SCHEMBL23553939 | 0.80 | ROCK2 (0.60) | ROCK2ROCK1MEP1BMMP13PRKD1 | |
| SCHEMBL19954176 | 0.80 | SLC7A5 (0.57) | ROCK2ROCK1MEP1BKMT2AGAA | |
| SCHEMBL17788673 | 0.79 | ROCK2 (0.50) | ROCK2ROCK1MEP1BKMT2AGAA | |
| SCHEMBL19954249 | 0.78 | MEN1 (0.54) | ROCK2ROCK1KMT2A | |
| SCHEMBL19954230 | 0.77 | SMYD3 (0.61) | ROCK2ROCK1MEP1BKMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914740-B2 | Tricyclic pyrido-carboxamide derivatives as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-13 | — | — | US | disclosed |