Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 13/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14114856 | 0.84 | POLB (0.64) | POLBATML3MBTL1P2RX7LMNA | |
| SCHEMBL25588069 | 0.84 | ALDH1A1 (0.42) | POLBSMN1; SMN2P2RX7ALDH1A1HPGD | |
| SCHEMBL12312605 | 0.82 | P2RX7 (0.44) | SMN1; SMN2L3MBTL1P2RX7ALDH1A1CYP2D6 | |
| SCHEMBL19954232 | 0.80 | HTR2C (0.43) | P2RX7CYP2D6PKMCYP2C19 | |
| SCHEMBL19954177 | 0.78 | LMNA (0.64) | POLBATML3MBTL1ALDH1A1LMNA | |
| SCHEMBL23095179 | 0.76 | NPC1 (0.38) | SMN1; SMN2P2RX7ALDH1A1CYP2C19 | |
| SCHEMBL19954188 | 0.76 | HTT (0.45) | P2RX7CYP2D6PKMCYP2C19 | |
| SCHEMBL13995328 | 0.75 | P2RX7 (0.43) | SMN1; SMN2L3MBTL1P2RX7 | |
| SCHEMBL13644157 | 0.74 | CYP2D6 (0.44) | P2RX7ALDH1A1CYP2D6PKMCYP2C19 | |
| SCHEMBL31136802 | 0.74 | CYP2D6 (0.44) | P2RX7ALDH1A1CYP2D6PKMCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914740-B2 | Tricyclic pyrido-carboxamide derivatives as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-13 | — | — | US | disclosed |