Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.59 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.57 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.57 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MEP1B | Q16820 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SENP1 | Q9P0U3 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19954171 | 0.87 | LOXL2 (0.57) | LOXL2CYP4F2CYP4A11SLC7A5HIF1A | |
| SCHEMBL19954228 | 0.85 | MEP1B (0.63) | HIF1AFOLH1MRGPRX4ALDH1A1MEP1B | |
| SCHEMBL12176728 | 0.85 | LOXL2 (0.62) | LOXL2CYP4F2CYP4A11SLC7A5HIF1A | |
| SCHEMBL19954263 | 0.84 | MEP1B (0.48) | FOLH1ALDH1A1MEP1BKMT2A | |
| SCHEMBL1287402 | 0.81 | LOXL2 (0.54) | LOXL2CYP4F2CYP4A11ALDH1A1MAPT | |
| SCHEMBL21579366 | 0.81 | LOXL2 (0.70) | LOXL2CYP4F2CYP4A11SLC7A5HIF1A | |
| SCHEMBL126284 | 0.81 | LOXL2 (0.74) | LOXL2CYP4F2CYP4A11SLC7A5HIF1A | |
| SCHEMBL14143797 | 0.80 | LOXL2 (0.64) | LOXL2CYP4F2CYP4A11SLC7A5HIF1A | |
| SCHEMBL45633 | 0.80 | LOXL2 (0.68) | LOXL2CYP4F2CYP4A11SLC7A5HIF1A | |
| SCHEMBL10106354 | 0.79 | SLC7A5 (0.65) | LOXL2CYP4F2CYP4A11SLC7A5HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914740-B2 | Tricyclic pyrido-carboxamide derivatives as rock inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-03-13 | — | — | US | disclosed |