Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | USP18 | Q9UMW8 | 2/20 | 0.43 |
| ▸ | UCHL5 | Q9Y5K5 | 2/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 3/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19954682 | 0.98 | CASP3 (0.50) | CASP3USP18UCHL5PSMB5MAPT | |
| SCHEMBL17693760 | 0.87 | CASP3 (0.53) | CASP3USP18UCHL5PSMB5MAPT | |
| SCHEMBL25003481 | 0.84 | CASP3 (0.50) | CASP3USP18UCHL5PSMB5MAPT | |
| SCHEMBL17693738 | 0.84 | CASP3 (0.58) | CASP3USP18UCHL5PSMB5MAPT | |
| SCHEMBL19954680 | 0.83 | PAX8 (0.44) | PSMB5MAPTACHEHSP90AA1MEN1 | |
| SCHEMBL17693740 | 0.82 | CASP3 (0.56) | CASP3USP18UCHL5MAPTACHE | |
| SCHEMBL21137783 | 0.79 | TDP1 (0.44) | CASP3MEN1MAPK1KMT2A | |
| SCHEMBL25183349 | 0.79 | CASP3 (0.46) | CASP3PSMB5MAPTACHEBCL2 | |
| SCHEMBL25183347 | 0.79 | CASP3 (0.46) | CASP3PSMB5MAPTACHEBCL2 | |
| SCHEMBL25183346 | 0.79 | CASP3 (0.46) | CASP3PSMB5MAPTACHEBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9913834-B2 | Bis-benzylidine piperidone proteasome inhibitor with anticancer activity | THE JOHNS HOPKINS UNIVERSITY (US) | 2018-03-13 | — | — | US | disclosed |