Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.30 |
| ▸ | PIM1 | P11309 | 1/20 | 0.30 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.30 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21023766 | 0.84 | PLAT (0.38) | PLATMAPK1NR3C2PDE4BPDE3A | |
| SCHEMBL19954572 | 0.81 | MAPK1 (0.36) | PLATMAPK1NR3C2PDE4BPDE3A | |
| SCHEMBL21024103 | 0.77 | TRPV1 (0.42) | NR3C2PDE4BTGFBR1TRPV1LRRK2 | |
| SCHEMBL21023833 | 0.77 | TRPV1 (0.40) | NR3C2PDE4BTGFBR1TRPV1GRIA2 | |
| SCHEMBL19954622 | 0.74 | GAA (0.37) | NR3C2TGFBR1TRPV1IRAK4LRRK2 | |
| SCHEMBL19954551 | 0.72 | TRPV1 (0.35) | NR3C2TGFBR1TRPV1GRIA2LRRK2 | |
| SCHEMBL19954609 | 0.70 | TRPV1 (0.42) | NR3C2TRPV1ARGRIA2LRRK2 | |
| SCHEMBL21023570 | 0.69 | NR3C2 (0.38) | NR3C2TRPV1 | |
| SCHEMBL19954602 | 0.68 | AR (0.41) | TRPV1ARGRIA2LRRK2 | |
| SCHEMBL19954640 | 0.67 | CCNT1 (0.36) | NR3C2TGFBR1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914706-B2 | N-substituted pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2018-03-13 | — | — | US | disclosed |