Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAT | P00750 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19954668 | 0.84 | PLAT (0.36) | PLATMAPK1NR3C2PDE4BPDE3A | |
| SCHEMBL19954572 | 0.84 | MAPK1 (0.36) | PLATMAPK1NR3C2PDE4BPDE3A | |
| SCHEMBL14638771 | 0.80 | PLAT (0.45) | PLATGAANR3C2TGFBR1IRAK4 | |
| SCHEMBL21023567 | 0.79 | CRBN (0.37) | PLATGAANR3C2PDE4BPDE3A | |
| SCHEMBL21780763 | 0.78 | GAA (0.40) | GAANR3C2TGFBR1LMNAKDM4E | |
| SCHEMBL21023577 | 0.78 | TGFBR1 (0.44) | PLATGAATGFBR1 | |
| SCHEMBL18164107 | 0.75 | GAA (0.41) | GAANR3C2TGFBR1LMNAKDM4E | |
| SCHEMBL21024096 | 0.75 | GAA (0.44) | GAANR3C2TGFBR1LMNAKDM4E | |
| SCHEMBL12912163 | 0.74 | GAA (0.43) | GAANR3C2LMNAKDM4E | |
| SCHEMBL18163942 | 0.72 | GAA (0.39) | MAPK1GAANR3C2TGFBR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080087-B1 | N-SUBSTITUTED PYRAZOLYL GUANIDINE F1F0-ATPASE INHIBITORS AND THERAPEUTIC USES THEREOF | LYCERA CORP (US) | 2019-05-22 | — | — | EP | disclosed |