Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12305130 | 0.83 | — | — | |
| SCHEMBL15296215 | 0.79 | NAAA (0.35) | IL1BP2RX7NAAAASAH1 | |
| SCHEMBL16866836 | 0.79 | SCN9A (0.33) | IL1BP2RX7 | |
| SCHEMBL17815996 | 0.79 | APLNR (0.39) | — | |
| SCHEMBL20667438 | 0.79 | CYP1A2 (0.39) | — | |
| SCHEMBL12459488 | 0.77 | CYP1A2 (0.43) | — | |
| SCHEMBL16450611 | 0.76 | NAAA (0.33) | NAAAASAH1 | |
| SCHEMBL17811764 | 0.76 | EPHX2 (0.31) | — | |
| SCHEMBL22281713 | 0.73 | PIK3CD (0.34) | NAAA | |
| SCHEMBL12522182 | 0.73 | GNAO1 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9914723-B2 | Small molecule inhibitors of Mcl-1 and uses thereof | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2018-03-13 | — | — | US | disclosed |