Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19633485 | 0.87 | EHMT2 (0.35) | CCNT1CDK9ESR1 | |
| SCHEMBL15833953 | 0.85 | EHMT2 (0.35) | CCNT1CDK9ESR1 | |
| SCHEMBL19633400 | 0.84 | EHMT2 (0.36) | MAP3K12ESR1 | |
| SCHEMBL19633517 | 0.82 | EHMT2 (0.39) | CCNT1ESR1 | |
| SCHEMBL19957822 | 0.81 | ESR1 (0.33) | CCNT1CDK9MAP3K12ESR1HRH3 | |
| SCHEMBL15833940 | 0.81 | KCNN2 (0.38) | CCNT1CDK9BRD4 | |
| SCHEMBL15834078 | 0.77 | RXRA (0.32) | CCNT1CDK9ESR1HRH3 | |
| SCHEMBL21064102 | 0.77 | CCNT1 (0.38) | CCNT1CDK9MAP3K12ESR1HRH3 | |
| SCHEMBL17300802 | 0.77 | HRH4 (0.42) | CCNT1CDK9BRD4 | |
| SCHEMBL20252427 | 0.77 | CCNT1 (0.49) | CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |