Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 4/20 | 0.35 |
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.30 |
| ▸ | CA2 | P00918 | 2/20 | 0.30 |
| ▸ | CA9 | Q16790 | 2/20 | 0.30 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15833953 | 0.91 | EHMT2 (0.35) | EHMT2EHMT1ESR1CCNT1CDK9 | |
| SCHEMBL19633400 | 0.90 | EHMT2 (0.36) | EHMT2EHMT1ESR1CA1CA2 | |
| SCHEMBL19633517 | 0.88 | EHMT2 (0.39) | EHMT2EHMT1ESR1CCNT1 | |
| SCHEMBL19957555 | 0.87 | CCNT1 (0.33) | ESR1CCNT1CDK9 | |
| SCHEMBL17303810 | 0.86 | HCRTR1 (0.37) | EHMT2EHMT1CA1CA2CA9 | |
| SCHEMBL17300773 | 0.82 | EHMT2 (0.34) | EHMT2EHMT1CA1CA2CA9 | |
| SCHEMBL23304367 | 0.81 | NAPEPLD (0.39) | EHMT2EHMT1 | |
| SCHEMBL30260151 | 0.80 | NAPEPLD (0.41) | EHMT2EHMT1CA1CA2CA9 | |
| SCHEMBL23304406 | 0.79 | EHMT2 (0.36) | EHMT2EHMT1 | |
| SCHEMBL19957822 | 0.76 | ESR1 (0.33) | ESR1CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190343826-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. | 2019-11-14 | — | — | US | disclosed |
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | Epizyme, Inc. (US) | 2019-06-04 | — | — | US | disclosed |
| US-20170334861-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2017-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190343826-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT3 | EHMT2 24/4885EHMT1 20/4885ESR1 4409/4885 |
| US-10307413-B2 | Tetrahydro- and dihydro-isoquinoline PRMT5 inhibitors and uses thereof | PRMT5, PRMT1, PRMT3 | EHMT2 24/4885EHMT1 20/4885ESR1 4409/4885 |
| US-20170334861-A1 | TETRAHYDRO- AND DIHYDRO-ISOQUINOLINE PRMT5 INHIBITORS AND USES THEREOF | PRMT5, PRMT1, PRMT3 | EHMT2 24/4885EHMT1 20/4885ESR1 4409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.