Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.35 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.31 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.30 |
| ▸ | CDK9 | P50750 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19633485 | 0.91 | EHMT2 (0.35) | EHMT2EHMT1ESR1CCNT1CDK9 | |
| SCHEMBL19633400 | 0.89 | EHMT2 (0.36) | EHMT2EHMT1ESR1 | |
| SCHEMBL19633517 | 0.87 | EHMT2 (0.39) | EHMT2EHMT1ESR1CCNT1 | |
| SCHEMBL19957555 | 0.85 | CCNT1 (0.33) | ESR1CCNT1CDK9 | |
| SCHEMBL15830010 | 0.85 | DNM2 (0.40) | EHMT2EHMT1 | |
| SCHEMBL17300827 | 0.81 | EHMT2 (0.34) | EHMT2EHMT1 | |
| SCHEMBL17303810 | 0.77 | HCRTR1 (0.37) | EHMT2EHMT1CCNT1CDK9 | |
| SCHEMBL19957822 | 0.76 | ESR1 (0.33) | ESR1CCNT1CDK9 | |
| SCHEMBL19957516 | 0.75 | HCRTR1 (0.33) | ESR1 | |
| SCHEMBL19633518 | 0.74 | CCNT1 (0.36) | CCNT1CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015200677-A2 | PRMT5 INHIBITORS AND USES THEREOF | Epizyme, Inc. (US) | 2015-12-30 | — | — | WO | disclosed |
| WO-2014100730-A1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | Epizyme, Inc. (US) | 2014-06-26 | — | — | WO | disclosed |