Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 18/20 | 0.73 |
| ▸ | WDR77 | Q9BQA1 | 11/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19957533 | 0.87 | PRMT5 (0.74) | PRMT5WDR77 | |
| SCHEMBL19957640 | 0.87 | PRMT5 (0.71) | PRMT5WDR77KDM4EALDH1A1HPGD | |
| SCHEMBL15825537 | 0.85 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL15935388 | 0.85 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL15825539 | 0.85 | PRMT5 (1.00) | PRMT5WDR77 | |
| SCHEMBL19957697 | 0.84 | MTNR1A (0.60) | PRMT5WDR77KDM4ENPC1ALDH1A1 | |
| SCHEMBL15818387 | 0.80 | PRMT5 (0.69) | PRMT5WDR77KDM4ENPC1ALDH1A1 | |
| SCHEMBL19957605 | 0.79 | PRMT5 (0.72) | PRMT5WDR77GAAHPGD | |
| SCHEMBL19957637 | 0.78 | PRMT5 (0.71) | PRMT5WDR77 | |
| SCHEMBL19957667 | 0.76 | PRMT5 (0.66) | PRMT5WDR77 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |