Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.57 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 5/20 | 0.55 |
| ▸ | HTR2A | P28223 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.54 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.54 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19957643 | 0.89 | PRMT5 (0.67) | PRMT5WDR77ALDH1A1CYP2D6CYP3A4 | |
| SCHEMBL15834077 | 0.81 | PRMT5 (0.81) | PRMT5WDR77 | |
| SCHEMBL15833951 | 0.81 | PRMT5 (0.81) | PRMT5WDR77 | |
| SCHEMBL15834007 | 0.81 | PRMT5 (0.81) | PRMT5WDR77 | |
| SCHEMBL19957941 | 0.79 | PRMT5 (0.64) | PRMT5WDR77 | |
| SCHEMBL23004926 | 0.78 | ACHE (0.68) | PRMT5WDR77DRD2HTR2A | |
| SCHEMBL7237584 | 0.78 | DRD2 (0.62) | PRMT5WDR77ALDH1A1CYP2D6CYP3A4 | |
| SCHEMBL20502177 | 0.77 | DRD2 (0.66) | PRMT5WDR77CYP2D6CYP3A4DRD2 | |
| SCHEMBL491722 | 0.77 | ALDH1A1 (0.80) | ALDH1A1CYP2D6CYP3A4CYP1A2MAPT | |
| SCHEMBL19957570 | 0.77 | ALDH1A1 (0.71) | PRMT5WDR77ALDH1A1CYP2D6DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935243-B1 | PRMT5 INHIBITORS CONTAINING A DIHYDRO- OR TETRAHYDROISOQUINOLINE AND USES THEREOF | EPIZYME INC (US) | 2018-03-14 | — | — | EP | disclosed |