Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19959008 | 0.95 | ACHE (0.36) | CHRM5ADRA2CACHE | |
| SCHEMBL19959014 | 0.86 | ACHE (0.34) | ACHE | |
| SCHEMBL19959066 | 0.84 | KCNH2 (0.40) | CHRM5ADRA2CACHE | |
| SCHEMBL118241 | 0.84 | CHRM5 (0.41) | CHRM5ADRA2CACHE | |
| SCHEMBL17886018 | 0.83 | SIGMAR1 (0.37) | — | |
| SCHEMBL21673372 | 0.82 | HTR2A (0.37) | CHRM5ADRA2CACHE | |
| SCHEMBL20314500 | 0.80 | ACHE (0.37) | CHRM5ADRA2CACHE | |
| SCHEMBL19959065 | 0.80 | KCNH2 (0.42) | CHRM5ADRA2CACHE | |
| SCHEMBL17282109 | 0.79 | NCF1 (0.38) | CHRM5ADRA2CACHE | |
| SCHEMBL20314548 | 0.79 | ACHE (0.36) | CHRM5ADRA2CACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180072711-A1 | INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ARVINAS OPERATIONS, INC. | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072711-A1 | INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | ESR1, GPER1, ESR2 | CHRM5 240/4885ADRA2C 91/4885ACHE 518/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.