Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23468026 | 0.80 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8276888 | 0.78 | ALDH1A1 (0.53) | POLBKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL19952980 | 0.78 | ALDH3A1 (0.44) | POLBKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL4250096 | 0.76 | ALDH1A1 (0.52) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL18516333 | 0.76 | SMN1; SMN2 (0.44) | POLBKDM4EALDH1A1HPGDL3MBTL1 | |
| SCHEMBL8276917 | 0.76 | MALT1 (0.44) | POLBKDM4EALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL20726687 | 0.76 | SMN1; SMN2 (0.49) | POLBALDH1A1SMN1; SMN2TSHRMEN1 | |
| SCHEMBL8276880 | 0.76 | SMN1; SMN2 (0.50) | POLBKDM4EALDH1A1MAPTL3MBTL1 | |
| SCHEMBL11983508 | 0.75 | MAPK14 (0.56) | POLBKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL19172634 | 0.75 | SMN1; SMN2 (0.47) | POLBKDM4EALDH1A1HPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049296-A1 | HETEROARYL INHIBITORS OF PAD4 | PADLOCK THERAPEUTICS, INC. (US) | 2018-03-15 | — | — | WO | disclosed |