Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 1/20 | 0.66 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 2/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | PDE6D | O43924 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953654 | 0.84 | GRM7 (0.62) | GRM7GAAMTNR1AMTNR1B | |
| SCHEMBL19953513 | 0.84 | GRM7 (0.62) | GRM7GAAMTNR1AMTNR1B | |
| SCHEMBL19953501 | 0.84 | GRM7 (0.61) | GRM7HDAC4HDAC7HDAC5ACE | |
| SCHEMBL19953496 | 0.84 | GRM7 (0.61) | GRM7HDAC4HDAC7HDAC5ACE | |
| SCHEMBL19960496 | 0.83 | GRM7 (0.60) | GRM7HDAC4HDAC7HDAC5ACE | |
| SCHEMBL19960416 | 0.83 | GRM7 (0.60) | GRM7HDAC4HDAC7HDAC5ACE | |
| SCHEMBL20113021 | 0.82 | GRM7 (0.78) | GRM7LMNAGAA | |
| SCHEMBL20113020 | 0.82 | GRM7 (0.68) | GRM7GAA | |
| SCHEMBL19960507 | 0.81 | GRM7 (0.58) | GRM7HDAC4HDAC7HDAC5LMNA | |
| SCHEMBL20113096 | 0.81 | GRM7 (0.55) | GRM7FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |