Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 1/20 | 0.60 |
| ▸ | ANPEP | P15144 | 2/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
| ▸ | PDE6D | O43924 | 1/20 | 0.36 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953501 | 0.88 | GRM7 (0.61) | GRM7FFAR1ACEOPRM1OPRL1 | |
| SCHEMBL19953496 | 0.88 | GRM7 (0.61) | GRM7FFAR1ACEOPRM1OPRL1 | |
| SCHEMBL19960496 | 0.86 | GRM7 (0.60) | GRM7ANPEPFFAR1ACEOPRM1 | |
| SCHEMBL19960417 | 0.83 | GRM7 (0.66) | GRM7FFAR1ACEOPRM1OPRL1 | |
| SCHEMBL20113096 | 0.81 | GRM7 (0.55) | GRM7FFAR1KCNH2 | |
| SCHEMBL19960922 | 0.81 | CYP2C9 (0.43) | GRM7ACEOPRM1OPRL1OPRK1 | |
| SCHEMBL19953513 | 0.80 | GRM7 (0.62) | GRM7 | |
| SCHEMBL19953654 | 0.80 | GRM7 (0.62) | GRM7 | |
| SCHEMBL19960661 | 0.80 | GRM7 (0.53) | GRM7FFAR1ACEHTR2AHTR2C | |
| SCHEMBL19953548 | 0.80 | GRM7 (0.53) | GRM7FFAR1ACEHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |