Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953666 | 0.83 | HDAC4 (0.44) | HDAC4HDAC7HDAC5KMT2AMEN1 | |
| SCHEMBL19953665 | 0.78 | LMNA (0.44) | LMNAALDH1A1KDM4E | |
| SCHEMBL2992029 | 0.76 | HDAC4 (0.67) | HDAC4HDAC7HDAC5KMT2AMEN1 | |
| SCHEMBL38661846 | 0.76 | HDAC4 (0.67) | HDAC4HDAC7HDAC5KMT2AMEN1 | |
| SCHEMBL29209003 | 0.71 | HDAC4 (0.40) | HDAC4HDAC7HDAC5KMT2AMEN1 | |
| SCHEMBL3772600 | 0.71 | HDAC4 (0.55) | HDAC4HDAC7HDAC5KMT2AMEN1 | |
| SCHEMBL19960632 | 0.69 | EGFR (0.43) | L3MBTL1MAPTEGFRALDH1A1KDM4E | |
| SCHEMBL11776203 | 0.66 | HDAC4 (0.52) | HDAC4HDAC7HDAC5KMT2AMEN1 | |
| SCHEMBL11780985 | 0.66 | HDAC4 (0.52) | HDAC4HDAC7HDAC5KMT2AMEN1 | |
| SCHEMBL4988285 | 0.66 | PSEN1 (0.50) | HDAC4HDAC7HDAC5KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |