Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 6/20 | 0.34 |
| ▸ | GRM7 | Q14831 | 2/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.31 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.30 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19953582 | 0.67 | GRM7 (0.41) | GRM7TRPV1 | |
| SCHEMBL19953542 | 0.62 | GRM7 (0.41) | GRM7TRPV1 | |
| SCHEMBL9028558 | 0.60 | MEN1 (0.50) | — | |
| SCHEMBL20257893 | 0.59 | GRM7 (0.49) | PRMT5GRM7HRH3 | |
| SCHEMBL16506973 | 0.58 | TRIM24 (0.49) | — | |
| SCHEMBL19657308 | 0.58 | CASP3 (0.43) | — | |
| SCHEMBL6748962 | 0.58 | NOTUM (0.45) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL19960700 | 0.58 | GRM7 (0.43) | GRM7TRPV1 | |
| SCHEMBL19960564 | 0.58 | HRH3 (0.40) | PRMT5GRM7HRH3 | |
| SCHEMBL19953584 | 0.58 | FABP5 (0.43) | GRM7HRH3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018047983-A1 | INDANE DERIVATIVES USEFUL AS MODULATORS OF MGLUR7 | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2018-03-15 | — | — | WO | disclosed |