Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 3/20 | 0.68 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | PCSK9 | Q8NBP7 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL865051 | 0.84 | LOXL2 (0.72) | LOXL2PIN1DAOCA12CA9 | |
| SCHEMBL8296766 | 0.82 | LOXL2 (0.70) | LOXL2PIN1DAOCA12CA9 | |
| SCHEMBL19953415 | 0.81 | LOXL2 (1.00) | LOXL2PIN1DAOCA12CA9 | |
| SCHEMBL11865173 | 0.81 | LOXL2 (0.68) | LOXL2PIN1DAOCA12CA9 | |
| SCHEMBL11163173 | 0.81 | LOXL2 (0.68) | LOXL2PIN1DAOCA12CA9 | |
| SCHEMBL12334164 | 0.78 | LOXL2 (0.64) | LOXL2PIN1DAOCA12CA9 | |
| SCHEMBL6850105 | 0.78 | LOXL2 (0.74) | LOXL2PIN1DAOCA12CA9 | |
| Hydrochloric Acid SCHEMBL2271950 | 0.77 | LOXL2 (0.72) | LOXL2PIN1DAOCA12CA9 | |
| SCHEMBL14794969 | 0.77 | LOXL2 (0.62) | LOXL2PIN1DAOCA12CA9 | |
| SCHEMBL31065503 | 0.77 | LOXL2 (0.62) | LOXL2PIN1DAOCA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048930-A1 | LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |