Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.45 |
| ▸ | HTR1D known ✓ | P28221 | 1/20 | 0.45 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.42 |
| ▸ | LOXL2 | Q9Y4K0 | 4/20 | 0.72 |
| ▸ | RAB9A | P51151 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6850105 | 0.98 | LOXL2 (0.74) | LOXL2HTR2AHTR1DRAB9ANPC1 | |
| SCHEMBL31406127 | 0.84 | LOXL2 (0.54) | LOXL2HTR2AHTR1DDAOCA12 | |
| SCHEMBL11806220 | 0.84 | LOXL2 (0.54) | LOXL2HTR2AHTR1DDAOCA12 | |
| SCHEMBL19953415 | 0.84 | LOXL2 (1.00) | LOXL2RAB9ANPC1PIN1DAO | |
| SCHEMBL865051 | 0.83 | LOXL2 (0.72) | LOXL2RAB9ANPC1PIN1DAO | |
| SCHEMBL8296766 | 0.78 | LOXL2 (0.70) | LOXL2RAB9ANPC1PIN1DAO | |
| SCHEMBL31190977 | 0.77 | CYP1A2 (0.47) | LOXL2HTR2AHTR1DHSD17B10MAPT | |
| SCHEMBL11811160 | 0.77 | IDO1 (0.49) | LOXL2HTR2ADAOKDM4EALDH1A1 | |
| SCHEMBL3052921 | 0.77 | LOXL2 (0.58) | LOXL2RAB9ANPC1PIN1DAO | |
| SCHEMBL6803154 | 0.77 | LOXL2 (0.77) | LOXL2HTR2AHTR1DRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 78 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108623511-A | A kind of indole amides class compound can be used for treating cancer | 南华大学 | 2018-10-09 | — | — | CN | claimed |
| EP-1420021-A1 | DNA Methyltransferase inhibitors | The Penn State Research Foundation (US) | 2004-05-19 | — | — | EP | claimed |
| CN-1370170-A | DNA methyltransferase inhibitors | PENN STATE RES FOUND (US) | 2002-09-18 | — | — | CN | claimed |
| US-20250257033-A1 | METHYL SUBSTITUTED QUATERNARY TRYPTAMINE DERIVATIVES | CAAMTECH INC (US) | 2025-08-14 | — | — | US | disclosed |
| EP-4561990-A1 | METHYL SUBSTITUTED QUATERNARY TRYPTAMINE DERIVATIVES | Caamtech, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| CN-118290427-A | N-substituted pyrazolo [3,4-d ] pyrimidinone compound and application thereof | 中山大学 | 2024-07-05 | — | — | CN | disclosed |
| WO-2024118767-A2 | TRYPTAMINE DERIVATIVES | CAAMTECH, INC. (US) | 2024-06-06 | — | — | WO | disclosed |
| WO-2024026291-A1 | METHYL SUBSTITUTED QUATERNARY TRYPTAMINE DERIVATIVES | CAAMTECH, INC. (US) | 2024-02-01 | — | — | WO | disclosed |
| CN-110776510-B | Preparation method of 1- (2-quinolyl) -beta-carboline natural product and derivative | 烟台大学 | 2022-05-31 | — | — | CN | disclosed |
| US-20210002265-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY | Université de Lausanne (CH) | 2021-01-07 | — | — | US | disclosed |
| EP-3759104-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY | Université de Lausanne (CH) | 2021-01-06 | — | — | EP | disclosed |
| US-5300645-A | Condensation of cycloalkyl-, phenyl- or naphthylpyrrole ethylamines with a 2-oxazolidinone to get antiserotonine agent | ELI LILLY AND COMPANY (US) | 1994-04-05 | — | — | US | disclosed |
| EP-0520987-A1 | METHOD OF SUPPRESSING APPETITE BY ADMINISTRATION OF TETRAHYDRO-$g(b)-CARBOLINE DERIVATIVES | NEUREX CORPORATION (US) | 1993-01-07 | — | — | EP | disclosed |
| US-5169852-A | Anorexigenic agents | NEUREX CORPORATION (US) | 1992-12-08 | — | — | US | disclosed |
| EP-0520987-A4 | METHOD OF SUPPRESSING APPETITE BY ADMINISTRATION OF TETRAHYDRO--g(b)-CARBOLINE DERIVATIVES. | NEUREX CORP (US) | 1992-05-13 | — | — | EP | disclosed |
| US-4978669-A | ALTERING MACRONUTRIENT PREFERENCE | NEUREX CORPORATION (US) | 1990-12-18 | — | — | US | disclosed |
| WO-1990014827-A1 | METHOD OF SUPPRESSING APPETITE BY ADMINISTRATION OF TETRAHYDRO-β-CARBOLINE DERIVATIVES | NEUREX CORPORATION (US) | 1990-12-13 | — | — | WO | disclosed |
| US-4358451-A | ANOXIA, PSYCHOTROPIC | SYNTHELABO (FR) | 1982-11-09 | — | — | US | disclosed |
| US-4336256-A | TREATMENT OF ANOXIA, DEPRESSION AND IN PSYCHOTROPIC THERAPY | SYNTHELABO (FR) | 1982-06-22 | — | — | US | disclosed |
| US-4272539-A | ANOXIA, ANTIDEPRESSANTS | SYNTHELABO (FR) | 1981-06-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002265-A1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF THE WNT SIGNALLING PATHWAY | WNT1, WNT3A, WNT3 | HTR2A 3434/4885HTR1D 2952/4885HRH1 2172/4885 |
| US-20250257033-A1 | METHYL SUBSTITUTED QUATERNARY TRYPTAMINE DERIVATIVES | INMT, TMT1A, SLC6A4 | HTR2A 75/4885HTR1D 89/4885HRH1 3445/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.