Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 2/20 | 0.32 |
| ▸ | PRKDC | P78527 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.31 |
| ▸ | CCNC | P24863 | 1/20 | 0.30 |
| ▸ | CDK8 | P49336 | 1/20 | 0.30 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.30 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1044209 | 0.84 | ALDH1A1 (0.35) | ERN1KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL567898 | 0.84 | CCNC (0.34) | ERN1PRKDCCCNCCDK8 | |
| SCHEMBL1563913 | 0.74 | ALDH1A1 (0.38) | ERN1MEN1ALDH1A1KMT2ACCNC | |
| SCHEMBL6920756 | 0.74 | MEN1 (0.38) | KDM4EMEN1ALDH1A1LMNAHPGD | |
| SCHEMBL29923236 | 0.74 | CCNC (0.33) | ERN1CCNCCDK8 | |
| SCHEMBL782488 | 0.74 | CA1 (0.31) | CCNCCDK8 | |
| SCHEMBL30702047 | 0.74 | CA1 (0.31) | CCNCCDK8 | |
| SCHEMBL15144851 | 0.74 | ERN1 (0.31) | ERN1KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL17508485 | 0.74 | HPGD (0.33) | MEN1ALDH1A1LMNAHPGDKMT2A | |
| SCHEMBL17508483 | 0.74 | HPGD (0.33) | MEN1ALDH1A1LMNAHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180071286-A1 | HETEROARYL PYRIDONE AND AZA-PYRODINE COMPOUNDS | GENENTECH, INC. (US) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180071286-A1 | HETEROARYL PYRIDONE AND AZA-PYRODINE COMPOUNDS | TYK2, BTK, PDXK | ERN1 1402/4885PRKDC 64/4885KDM4E 1084/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.