Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.52 |
| ▸ | OTC | P00480 | 1/20 | 0.46 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.43 |
| ▸ | ARG2 | P78540 | 4/20 | 0.43 |
| ▸ | ARG1 | P05089 | 3/20 | 0.43 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.42 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.42 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.42 |
| ▸ | ANPEP | P15144 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.41 |
| ▸ | DDAH1 | O94760 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 2/20 | 0.39 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | NOS2 | P35228 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24945952 | 0.87 | GSR (0.53) | GSROTCDPP7DPP8ARG2 | |
| SCHEMBL22375753 | 0.87 | GSR (0.53) | GSROTCDPP7DPP8ARG2 | |
| SCHEMBL18924694 | 0.87 | GSR (0.53) | GSROTCDPP7DPP8ARG2 | |
| SCHEMBL20192789 | 0.86 | GSR (0.56) | GSROTCDPP7DPP8ARG2 | |
| SCHEMBL22341247 | 0.85 | DDAH1 (0.46) | GSROTCDPP7DPP8ARG2 | |
| SCHEMBL19966782 | 0.85 | DPP7 (0.46) | GSROTCDPP7DPP8ARG2 | |
| SCHEMBL10017793 | 0.85 | DPP7 (0.46) | GSROTCDPP7DPP8ARG2 | |
| SCHEMBL14095770 | 0.83 | EPHX1 (0.52) | GSROTCDPP7ARG2ARG1 | |
| SCHEMBL9699185 | 0.83 | EPHX1 (0.52) | GSROTCDPP7ARG2ARG1 | |
| SCHEMBL13057095 | 0.83 | EPHX1 (0.52) | GSROTCDPP7ARG2ARG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11214779-B2 | Activatable CRISPR/CAS9 for spatial and temporal control of genome editing | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2022-01-04 | — | — | US | disclosed |
| US-20180073002-A1 | ACTIVATABLE CRISPR/CAS9 FOR SPATIAL AND TEMPORAL CONTROL OF GENOME EDITING | University of Pittsburgh - of the Commonwealth Sys tem of Higher Education (US) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11214779-B2 | Activatable CRISPR/CAS9 for spatial and temporal control of genome editing | KARS1, GDA, ZFR | GSR 4203/4885OTC 4022/4885DPP7 965/4885 |
| US-20180073002-A1 | ACTIVATABLE CRISPR/CAS9 FOR SPATIAL AND TEMPORAL CONTROL OF GENOME EDITING | KARS1, GDA, ZFR | GSR 4203/4885OTC 4022/4885DPP7 965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.