Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.68 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.68 |
| ▸ | JAK2 | O60674 | 3/20 | 0.57 |
| ▸ | RAF1 | P04049 | 2/20 | 0.57 |
| ▸ | GSK3B | P49841 | 4/20 | 0.56 |
| ▸ | ABL1 | P00519 | 3/20 | 0.54 |
| ▸ | BCR | P11274 | 3/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.54 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.54 |
| ▸ | PRKCG | P05129 | 1/20 | 0.54 |
| ▸ | PRKCB | P05771 | 1/20 | 0.54 |
| ▸ | PRKCA | P17252 | 1/20 | 0.54 |
| ▸ | PRKCH | P24723 | 1/20 | 0.54 |
| ▸ | PRKCI | P41743 | 1/20 | 0.54 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.54 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21074032 | 0.93 | BRAF (0.64) | BRAFMAPK14JAK2RAF1GSK3B | |
| SCHEMBL21074128 | 0.91 | BRAF (0.65) | BRAFMAPK14JAK2RAF1GSK3B | |
| SCHEMBL21074040 | 0.89 | BRAF (0.60) | BRAFMAPK14JAK2RAF1GSK3B | |
| SCHEMBL21074039 | 0.89 | BRAF (0.60) | BRAFMAPK14JAK2RAF1ABL1 | |
| SCHEMBL19966882 | 0.89 | BRAF (0.62) | BRAFMAPK14JAK2RAF1GSK3B | |
| SCHEMBL21074046 | 0.89 | BRAF (0.64) | BRAFMAPK14JAK2RAF1GSK3B | |
| SCHEMBL21116138 | 0.87 | BRAF (0.66) | BRAFMAPK14JAK2RAF1GSK3B | |
| SCHEMBL19966957 | 0.85 | BRAF (0.57) | BRAFMAPK14JAK2RAF1GSK3B | |
| SCHEMBL19966893 | 0.85 | BRAF (0.57) | BRAFMAPK14JAK2RAF1KDR | |
| SCHEMBL19966813 | 0.85 | ABL1 (0.59) | JAK2GSK3BABL1BCRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10793527-B2 | Adenosine monophosphate-activated protein kinase agonist | NATIONAL YANG-MING UNIVERSITY (TW) | 2020-10-06 | — | — | US | disclosed |
| US-20190194142-A1 | AN ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE AGONIST | NATIONAL YANG-MING UNIVERSITY (TW) | 2019-06-27 | — | — | US | disclosed |
| WO-2018045969-A1 | COMPOUND FOR ACTIVATING ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE | 法玛科技顾问股份有限公司 | 2018-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190194142-A1 | AN ADENOSINE MONOPHOSPHATE-ACTIVATED PROTEIN KINASE AGONIST | PRKAG1, PRKAG2, PRKAB1 | BRAF 1090/4885MAPK14 557/4885JAK2 1456/4885 |
| US-10793527-B2 | Adenosine monophosphate-activated protein kinase agonist | PRKAG1, PRKAG2, PRKAB1 | BRAF 1036/4885MAPK14 565/4885JAK2 1404/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.