Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 2/20 | 0.50 |
| ▸ | HTRA2 | O43464 | 8/20 | 0.49 |
| ▸ | HTRA1 | Q92743 | 8/20 | 0.49 |
| ▸ | ALB | P02768 | 2/20 | 0.48 |
| ▸ | WDR5 | P61964 | 1/20 | 0.45 |
| ▸ | SLC5A2 | P31639 | 2/20 | 0.43 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20047392 | 0.94 | FOLH1 (0.51) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL14932614 | 0.93 | HTRA2 (0.52) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL14932607 | 0.87 | HTRA2 (0.54) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL20235786 | 0.81 | HTRA2 (0.64) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL20235710 | 0.80 | HTRA2 (0.49) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL14932621 | 0.80 | HTRA2 (0.65) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL16234096 | 0.80 | HTRA2 (0.65) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL14932598 | 0.78 | HTRA2 (0.62) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL13833496 | 0.77 | HTRA2 (0.37) | FOLH1HTRA2HTRA1ALBWDR5 | |
| SCHEMBL14932664 | 0.77 | HTRA2 (0.58) | FOLH1HTRA2HTRA1ALBWDR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11377423-B2 | Inhibitors of histone deacetylase | THE BROAD INSTITUTE, INC. (US) | 2022-07-05 | — | — | US | disclosed |
| US-20180072671-A1 | INHIBITORS OF HISTONE DEACETYLASE | THE BROAD INSTITUTE, INC. (US) | 2018-03-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180072671-A1 | INHIBITORS OF HISTONE DEACETYLASE | HDAC3, HDAC1, HDAC11 | FOLH1 3632/4885HTRA2 3512/4885HTRA1 2051/4885 |
| US-11377423-B2 | Inhibitors of histone deacetylase | HDAC3, HDAC1, HDAC11 | FOLH1 3741/4885HTRA2 3610/4885HTRA1 2119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.