Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MYC | P01106 | 1/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.44 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.43 |
| ▸ | PTPRG | P23470 | 1/20 | 0.43 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5237193 | 0.84 | KDM4E (0.57) | KDM4EGLAMAPTPOLBMYC | |
| SCHEMBL11770114 | 0.81 | KDM4E (0.53) | KDM4EGLAMAPTPOLBMYC | |
| SCHEMBL11710082 | 0.80 | SIRT1 (0.50) | KDM4EGLAMAPTPOLBMYC | |
| SCHEMBL618056 | 0.74 | KDM4E (0.65) | KDM4EGLAMYCNR4A1GRIN1 | |
| SCHEMBL11785264 | 0.74 | KDM4E (0.46) | KDM4EGLAMAPTPOLBMYC | |
| SCHEMBL2473574 | 0.74 | KDM4E (0.46) | KDM4EGLAMAPTPOLBMYC | |
| SCHEMBL145485 | 0.74 | KDM4E (1.00) | KDM4EGLAMAPTPOLBMYC | |
| SCHEMBL29622752 | 0.74 | KDM4E (1.00) | KDM4EGLAMAPTPOLBMYC | |
| SCHEMBL3198739 | 0.73 | PTPRC (0.50) | KDM4EGLAPOLBMYCNR4A1 | |
| SCHEMBL490294 | 0.73 | MEN1 (0.48) | KDM4EGLAMAPTPOLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018049328-A1 | BICYCLIC COMPOUNDS USEFUL AS GPR120 MODULATORS | NUMERATE, INC. (US) | 2018-03-15 | — | — | WO | disclosed |