SCHEMBL145485

SCHEMBL145485

Nc1ccc(Br)cc1C(=O)O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 1.00
GLA P06280 1/20 1.00
MAPT P10636 4/20 0.67
POLB P06746 2/20 0.67
KMT2A Q03164 2/20 0.63
GFER P55789 1/20 0.63
RXFP1 Q9HBX9 1/20 0.63
APEX1 P27695 2/20 0.61
MEN1 O00255 1/20 0.61
USP2 O75604 1/20 0.61
THRB P10828 1/20 0.61
PKM P14618 1/20 0.61
RECQL P46063 1/20 0.61
BLM P54132 1/20 0.61
MCL1 Q07820 1/20 0.61
TDP1 Q9NUW8 1/20 0.61
PLAU P00749 1/20 0.59
KEAP1 Q14145 1/20 0.59
ALDH1A1 P00352 1/20 0.57
CDC25B P30305 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29622752 1.00 KDM4E (1.00) KDM4EGLAMAPTPOLBKMT2A
SCHEMBL10434364 0.88 KDM4E (0.77) KDM4EGLAMAPTPOLBKMT2A
Tetrahydrofuran SCHEMBL29092861 0.86 KDM4E (0.74) KDM4EGLAMAPTPOLBKMT2A
SCHEMBL6614986 0.86 KDM4E (0.74) KDM4EGLAMAPTPOLBKMT2A
SCHEMBL28171560 0.85 KDM4E (0.73) KDM4EGLAMAPTPOLBKMT2A
SCHEMBL5707564 0.83 KDM4E (0.71) KDM4EGLAMAPTPOLBKMT2A
SCHEMBL148392 0.83 KDM4E (0.70) KDM4EGLAMAPTPOLBKMT2A
SCHEMBL147774 0.83 KDM4E (0.70) KDM4EGLAMAPTPOLBKMT2A
SCHEMBL3898354 0.81 KDM4E (0.66) KDM4EGLAMAPTPOLBKMT2A
SCHEMBL9117837 0.81 KDM4E (0.66) KDM4EGLAMAPTPOLBKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1973 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119977844-A Preparation method of N-BOC-aniline derivative 上海泰坦科技股份有限公司 2025-05-13 CN claimed
WO-2025053634-A1 NOVEL QUINAZOLINE-BENZIMIDAZOLE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND USE THEREOF 고려대학교 산학협력단 2025-03-13 WO claimed
CN-119143662-A Preparation method of 2- (2-amino-5-bromo-benzoyl) pyridine 广西鲲宇药业有限公司 2024-12-17 CN claimed
CN-222057164-U Stirring device for preparing 2-amino-5-bromobenzoic acid 大连金点生物科技有限公司 2024-11-26 CN claimed
CN-118344355-A Quinazolinone derivative, preparation method thereof and application thereof in anti-inflammatory and anti-tumor 贵州省天然产物研究中心 2024-07-16 CN claimed
CN-118184526-A Preparation method of 2-amino-3-chlorobenzoic acid methyl ester 鹤壁市宝瑞德化工有限公司 2024-06-14 CN claimed
CN-114394924-B Organic two-state fluorescent molecular probe for viscosity detection and preparation method and application thereof 南昌大学 2024-06-04 CN claimed
CN-113912487-B Synthesis method of 2, 5-dihalobenzoic acid 山东研峰新材料科技有限公司 2024-05-28 CN claimed
CN-117924202-A Chrome-free tanning agent containing carboxylic acid sulfonate structure and preparation method thereof 浙江康诺和新材料有限公司 2024-04-26 CN claimed
CN-113461661-B 6- (pyridin-3-yl) quinazoline-4 (3H) -ketone derivative and preparation and application thereof 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 2023-11-28 CN claimed
CN-104177346-A Quinazoline compound and use thereof KEJIE BIO SUZHOU PHARMACEUTICALS CO LTD 2014-12-03 CN claimed
EP-1993992-B1 TETRAPHENYLNAPHTHALENE DERIVATIVES AND ORGANIC LIGHT EMITTING DIODE USING THE SAME LG CHEMICAL LTD (KR) 2014-11-26 EP claimed
US-20090174312-A1 Tetraphenylnaphalene Derivatives and Organic Light Emitting Diode Using the Same LG CHEM, LTD. (KR) 2009-07-09 US claimed
CN-101400643-A Tetraphenylnaphthalene derivative and organic light emitting diode using the same LG CHEMICAL LTD (KR) 2009-04-01 CN claimed
EP-1993992-A1 TETRAPHENYLNAPHTHALENE DERIVATIVES AND ORGANIC LIGHT EMITTING DIODE USING THE SAME LG Chem, Ltd. (KR) 2008-11-26 EP claimed
WO-2007105884-A1 TETRAPHENYLNAPHTHALENE DERIVATIVES AND ORGANIC LIGHT EMITTING DIODE USING THE SAME LG CHEM, LTD. (KR) 2007-09-20 WO claimed
US-6756486-B1 LAKED DISAZO YELLOW PIGMENTS HAVING DESIRABLE GREEN SHADE, HEAT STABILITY, GOOD STRENGTH, BLEED RESISTANCE, MIGRATION RESISTANCE, AND LOW OR NO TOXICITY ENGELHARD CORPORATION 2004-06-29 US claimed
US-6159585-A Security paper GEORGIA-PACIFIC CORPORATION (US) 2000-12-12 US claimed
US-5866608-A AROMATIC COMPOUNDS BIORESEARCH, INC. (US) 1999-02-02 US claimed
WO-1998041688-A1 SECURITY PAPER GEORGIA-PACIFIC CORPORATION, INC. (US) 1998-09-24 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090174312-A1 Tetraphenylnaphalene Derivatives and Organic Light Emitting Diode Using the Same CRY2, CRY1, PPOX KDM4E 3755/4885GLA 4086/4885MAPT 943/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.