Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | SLC34A1 | Q06495 | 5/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.31 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1025606 | 0.77 | GRM5 (0.38) | CRHR1SLC34A1MAPT | |
| SCHEMBL19967170 | 0.77 | PDE2A (0.41) | KMT2ACRHR1SLC34A1MEN1MAPT | |
| SCHEMBL19353716 | 0.74 | HEXA (0.39) | KMT2AMAPTCYP1A2 | |
| SCHEMBL1023884 | 0.73 | CYP1A2 (0.38) | KMT2ACRHR1TDP1MEN1MAPT | |
| SCHEMBL1023890 | 0.70 | MEN1 (0.36) | KMT2ASLC34A1MEN1CYP3A4CYP2C9 | |
| SCHEMBL14996540 | 0.69 | L3MBTL1 (0.44) | KMT2ASLC34A1TDP1L3MBTL1MAPT | |
| SCHEMBL1027586 | 0.68 | GRM8 (0.36) | CYP1A2 | |
| SCHEMBL1023290 | 0.68 | NR1H2 (0.36) | CRHR1 | |
| SCHEMBL1025914 | 0.66 | PDE10A (0.32) | — | |
| SCHEMBL1025108 | 0.65 | PDE10A (0.37) | SLC34A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018048969-A1 | MULTI-TARGETED HETEROCYCLIC COMPOUNDS FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2018-03-15 | — | — | WO | disclosed |