Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | GRM8 | O00222 | 1/20 | 0.44 |
| ▸ | GRM6 | O15303 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.44 |
| ▸ | GSR | P00390 | 1/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.44 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.44 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.44 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5084405 | 0.89 | ALDH1A1 (0.44) | ALDH1A1SLC1A5TDP1MAPK1HIF1A | |
| SCHEMBL5084403 | 0.89 | ALDH1A1 (0.44) | ALDH1A1SLC1A5TDP1MAPK1HIF1A | |
| SCHEMBL5078448 | 0.88 | CYP1A2 (0.46) | ALDH1A1SLC1A5CYP1A2GRM8GRM6 | |
| SCHEMBL21291549 | 0.88 | CYP1A2 (0.46) | ALDH1A1SLC1A5CYP1A2GRM8GRM6 | |
| SCHEMBL28374594 | 0.88 | ALDH1A1 (0.42) | ALDH1A1SLC1A5TDP1MAPK1HIF1A | |
| Hydrochloric Acid SCHEMBL31375791 | 0.88 | ALDH1A1 (0.42) | ALDH1A1SLC1A5TDP1MAPK1HIF1A | |
| SCHEMBL28170754 | 0.86 | ALDH1A1 (0.41) | ALDH1A1SLC1A5TDP1MAPK1HIF1A | |
| Hydrochloric Acid SCHEMBL6751555 | 0.84 | SLC1A5 (0.51) | ALDH1A1SLC1A5TDP1MAPK1HIF1A | |
| SCHEMBL21081465 | 0.83 | ALDH1A1 (0.47) | ALDH1A1SLC1A5TDP1MAPK1HIF1A | |
| SCHEMBL10390365 | 0.83 | ALDH1A1 (0.41) | ALDH1A1SLC1A5TDP1MAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10654858-B2 | Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2020-05-19 | — | — | US | claimed |
| CN-107442038-B | Ultraviolet response amino acid surfactant and preparation method thereof | 广州天赐高新材料股份有限公司 | 2019-08-09 | — | — | CN | claimed |
| US-20190211019-A1 | TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF | DUQUESNE UNIVERSITY OF THE HOLY GHOST | 2019-07-11 | — | — | US | claimed |
| CN-109553619-A | A kind of preparation method of methotrexate (MTX) | 北京斯利安药业有限公司 | 2019-04-02 | — | — | CN | claimed |
| US-10208051-B2 | Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2019-02-19 | — | — | US | claimed |
| US-20180162863-A1 | TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2018-06-14 | — | — | US | claimed |
| US-9896455-B2 | Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT (US) | 2018-02-20 | — | — | US | claimed |
| CN-107442038-A | Ultraviolet response amino acid surfactant and preparation method thereof | 广州天赐高新材料股份有限公司 | 2017-12-08 | — | — | CN | claimed |
| US-20170223990-A1 | FOOD PRESERVATION WITH FOLATES | UNIVERSITY OF CALCUTTA (IN) | 2017-08-10 | — | — | US | claimed |
| US-20160355520-A1 | Tricyclic Compounds Having Cytostatic and/or Cytotoxic Activity and Methods of Use Thereof | DUQUESNE UNIVERSITY OF THE HOLY GHOST | 2016-12-08 | — | — | US | claimed |
| US-20150141445-A1 | Tricyclic Compounds Having Cytostatic and/or Cytotoxic Activity and Methods of Use Thereof | DUQUESNE UNIVERSITY OF THE HOLY GHOST | 2015-05-21 | — | — | US | claimed |
| EP-2807927-A1 | Tricyclic Compounds Having Cytostatic and/or Cytotoxic Activity and Methods of Use Thereof | Duquesne University of the Holy Ghost (US) | 2014-12-03 | — | — | EP | claimed |
| EP-2200437-B1 | TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF | UNIV HOLY GHOST DUQUESNE (US) | 2014-07-30 | — | — | EP | claimed |
| US-20130102623-A1 | Tricyclic Compounds Having Cytostatic and/or Cytotoxic Activity and Methods of Use Thereof | DUQUESNE UNIVERSITY OF THE HOLY GHOST | 2013-04-25 | — | — | US | claimed |
| US-8314114-B2 | Tricyclic compounds having cytostatic and/or cytoxic activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2012-11-20 | — | — | US | claimed |
| US-20110207757-A1 | Tricyclic Compounds Having Cytostatic and/or Cytoxic Activity and Methods of Use Thereof | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2011-08-25 | — | — | US | claimed |
| US-7960400-B2 | Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2011-06-14 | — | — | US | claimed |
| EP-2200437-A1 | TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF | Duquesne University of the Holy Ghost (US) | 2010-06-30 | — | — | EP | claimed |
| US-20090062318-A1 | TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF | DUQUESNE UNIVERSITY OF THE HOLY GHOST | 2009-03-05 | — | — | US | claimed |
| WO-2009029473-A1 | TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF | DUQUESNE UNIVERSITY OF THE HOLY GHOST (US) | 2009-03-05 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162863-A1 | TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF | DHFR, TK1, TYMS | ALDH1A1 763/4885SLC1A5 1615/4885CYP1A2 2550/4885 |
| US-20090062318-A1 | TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF | DHFR, TK1, TYMS | ALDH1A1 763/4885SLC1A5 1615/4885CYP1A2 2550/4885 |
| US-20160355520-A1 | Tricyclic Compounds Having Cytostatic and/or Cytotoxic Activity and Methods of Use Thereof | DHFR, TK1, TYMS | ALDH1A1 763/4885SLC1A5 1615/4885CYP1A2 2550/4885 |
| US-10208051-B2 | Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof | DHFR, TK1, TYMS | ALDH1A1 763/4885SLC1A5 1615/4885CYP1A2 2550/4885 |
| US-20130102623-A1 | Tricyclic Compounds Having Cytostatic and/or Cytotoxic Activity and Methods of Use Thereof | DHFR, TK1, TYMS | ALDH1A1 763/4885SLC1A5 1615/4885CYP1A2 2550/4885 |
| US-20190211019-A1 | TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF | DHFR, TK1, TYMS | ALDH1A1 763/4885SLC1A5 1615/4885CYP1A2 2550/4885 |
| US-20150141445-A1 | Tricyclic Compounds Having Cytostatic and/or Cytotoxic Activity and Methods of Use Thereof | DHFR, TK1, TYMS | ALDH1A1 763/4885SLC1A5 1615/4885CYP1A2 2550/4885 |
| US-20110207757-A1 | Tricyclic Compounds Having Cytostatic and/or Cytoxic Activity and Methods of Use Thereof | DHFR, TK1, TK2 | ALDH1A1 621/4885SLC1A5 2035/4885CYP1A2 1944/4885 |
| US-10654858-B2 | Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof | DHFR, TK1, TYMS | ALDH1A1 763/4885SLC1A5 1615/4885CYP1A2 2550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.