Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 8/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.37 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | MOGAT2 | Q3SYC2 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2000794 | 0.87 | MLNR (0.45) | MLNRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL1995199 | 0.85 | MLNR (0.58) | MLNRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL2856291 | 0.84 | MLNR (0.75) | MLNRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL2853455 | 0.82 | MLNR (0.69) | MLNRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL1997141 | 0.80 | MLNR (0.68) | MLNRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL1999746 | 0.79 | MLNR (1.00) | MLNRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL1995197 | 0.78 | MLNR (0.63) | MLNRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL1997887 | 0.77 | MLNR (0.82) | MLNR | |
| SCHEMBL2003279 | 0.75 | PRKAA2 (0.46) | MLNRKMT2AMEN1NPC1RAB9A | |
| SCHEMBL1997046 | 0.75 | MEN1 (0.48) | MLNRKMT2AMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |