Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.34 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1997143 | 0.87 | MLNR (0.64) | MLNRMEN1KMT2ANPC1MAPT | |
| SCHEMBL1996929 | 0.84 | KDM4E (0.46) | MLNRKDM4EMEN1KMT2ANAMPT | |
| SCHEMBL2849534 | 0.82 | MLNR (0.52) | MLNRKDM4EMEN1KMT2ANAMPT | |
| SCHEMBL2849498 | 0.80 | MLNR (0.51) | MLNRKDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL377505 | 0.79 | MLNR (0.36) | MLNRKDM4ENPC1MAPTRAB9A | |
| SCHEMBL2000792 | 0.78 | KDM4E (0.48) | MLNRKDM4EMEN1KMT2AMAPK1 | |
| SCHEMBL1996928 | 0.76 | GPR119 (0.49) | MLNRKDM4ECHRM4 | |
| SCHEMBL377570 | 0.75 | SIGMAR1 (0.37) | MLNRLMNAALDH1A1 | |
| SCHEMBL1703946 | 0.75 | ALDH1A1 (0.38) | KDM4EMEN1KMT2AMAPK1LMNA | |
| SCHEMBL377560 | 0.74 | KDM4E (0.45) | KDM4EMAPK1LMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |