Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | MLNR | O43193 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1995199 | 0.90 | MLNR (0.58) | MEN1NPC1RAB9AKMT2APTGDR2 | |
| SCHEMBL2003279 | 0.88 | PRKAA2 (0.46) | MEN1NPC1RAB9AKMT2APTGDR2 | |
| SCHEMBL1998344 | 0.87 | MLNR (0.44) | MEN1NPC1RAB9AKMT2APTGDR2 | |
| SCHEMBL2002044 | 0.84 | MLNR (0.42) | MEN1NPC1RAB9AKMT2APTGDR2 | |
| SCHEMBL1996929 | 0.83 | KDM4E (0.46) | MEN1NPC1RAB9AKMT2APTGDR2 | |
| SCHEMBL1996027 | 0.83 | S1PR1 (0.39) | MEN1RAB9AKMT2APTGDR2MLNR | |
| SCHEMBL1999298 | 0.81 | PRKAA2 (0.43) | MEN1NPC1RAB9AKMT2AMLNR | |
| SCHEMBL1995582 | 0.80 | MLNR (0.57) | MEN1KMT2AMLNRALDH1A1MAPK1 | |
| SCHEMBL1998242 | 0.79 | MLNR (0.60) | KMT2AMLNRALDH1A1GAASMN1; SMN2 | |
| SCHEMBL1999248 | 0.79 | MLNR (0.60) | KMT2AMLNRALDH1A1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |