Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKAA2 | P54646 | 5/20 | 0.46 |
| ▸ | MLNR | O43193 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MOGAT2 | Q3SYC2 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1999298 | 0.92 | PRKAA2 (0.43) | PRKAA2MLNRMEN1NPC1RAB9A | |
| SCHEMBL1995199 | 0.90 | MLNR (0.58) | PRKAA2MLNRMEN1NPC1RAB9A | |
| SCHEMBL1998344 | 0.90 | MLNR (0.44) | PRKAA2MLNRMEN1NPC1RAB9A | |
| SCHEMBL1997046 | 0.88 | MEN1 (0.48) | MLNRMEN1NPC1RAB9AKMT2A | |
| SCHEMBL2002044 | 0.87 | MLNR (0.42) | MLNRMEN1NPC1RAB9AKMT2A | |
| SCHEMBL1996929 | 0.87 | KDM4E (0.46) | MLNRMEN1NPC1RAB9AKMT2A | |
| SCHEMBL1995582 | 0.83 | MLNR (0.57) | MLNRMEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL1999380 | 0.82 | MEN1 (0.48) | MLNRMEN1NPC1RAB9AKMT2A | |
| SCHEMBL1999248 | 0.80 | MLNR (0.60) | MLNRKMT2AKDM4EUSP2ALDH1A1 | |
| SCHEMBL3659038 | 0.80 | MLNR (0.53) | PRKAA2MLNRMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964597-B2 | Piperazinyl-sulfonamide derivatives useful in the treatment of GPR38 receptor mediated diseases | GLAXO GROUP LIMITED (GB) | 2011-06-21 | — | — | US | disclosed |