Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 2/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.44 |
| ▸ | HTR6 | P50406 | 8/20 | 0.43 |
| ▸ | IDE | P14735 | 2/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.36 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
| ▸ | HTR1F | P30939 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16618718 | 0.90 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL19971372 | 0.87 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL19984047 | 0.87 | HTR6 (0.43) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL16619000 | 0.85 | HTR6 (0.46) | HTR6IDEHTR1ADRD2HTR1D | |
| SCHEMBL16619172 | 0.85 | HTR6 (0.46) | HTR6IDEHTR1ADRD2HTR1D | |
| SCHEMBL16619142 | 0.85 | HTR6 (0.42) | PDE4APDE4BPDE4CPDE4DHTR6 | |
| SCHEMBL16626404 | 0.84 | HTR6 (0.45) | HTR6IDENAMPTHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL16618778 | 0.83 | HTR6 (0.44) | HTR6IDENAMPTHTR1ADRD2 | |
| SCHEMBL16626409 | 0.83 | HTR6 (0.44) | HTR6IDEHTR1ADRD2HTR1D | |
| SCHEMBL28207663 | 0.83 | HTR6 (0.58) | HTR6IDEPLK1HTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3052484-B1 | SULFONYLINDOLE DERIVATIVES AND METHOD FOR PREPARING THE SAME | DAE WOONG PHARMA (KR) | 2018-03-21 | — | — | EP | claimed |