Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL19971552 | 1.00 | TLR8 (0.31) | TLR8MEN1APAF1NPC1PLA2G1B | |
| Hydrochloric Acid SCHEMBL19970349 | 0.90 | TLR8 (0.33) | TLR8MEN1APAF1NPC1PLA2G1B | |
| Hydrochloric Acid SCHEMBL19970352 | 0.90 | TLR8 (0.33) | TLR8MEN1APAF1NPC1PLA2G1B | |
| SCHEMBL19975875 | 0.90 | TLR8 (0.34) | TLR8 | |
| SCHEMBL19975874 | 0.83 | ACHE (0.31) | — | |
| Bromide SCHEMBL19970379 | 0.81 | EPHX1 (0.37) | — | |
| Bromide SCHEMBL19970376 | 0.81 | EPHX1 (0.37) | — | |
| Bromide SCHEMBL19971546 | 0.80 | CA1 (0.32) | — | |
| Bromide SCHEMBL19971547 | 0.80 | CA1 (0.32) | — | |
| SCHEMBL19975859 | 0.79 | CA1 (0.35) | TLR8MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512604-B1 | STABLE YELLOW IMIDAZOLIUM COMPOUNDS AND METHODS FOR THEIR USE | WELLA OPERATIONS US LLC (US) | 2023-05-31 | — | — | EP | disclosed |
| US-10093807-B2 | Stable yellow imidazolium compounds | NOXELL CORPORATION (US) | 2018-10-09 | — | — | US | disclosed |
| US-20180079907-A1 | Stable Yellow Imidazolium Compounds | WELLA OPERATIONS US, LLC | 2018-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10093807-B2 | Stable yellow imidazolium compounds | IK, NDUFV1, NDUFV2 | TLR8 3446/4885MEN1 1263/4885APAF1 4683/4885 |
| US-20180079907-A1 | Stable Yellow Imidazolium Compounds | IK, NDUFV1, NDUFV2 | TLR8 3446/4885MEN1 1263/4885APAF1 4683/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.