Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL325772 | 0.85 | ALOX5 (0.45) | ALOX5DHODHKMT2AALDH1A1NPC1 | |
| SCHEMBL28780034 | 0.85 | ALOX5 (0.45) | ALOX5DHODHKMT2AALDH1A1GLA | |
| SCHEMBL9838372 | 0.84 | ALOX5 (0.41) | ALOX5DHODHKMT2ANPC1RAB9A | |
| Phenoxazine SCHEMBL27458642 | 0.81 | ALOX5 (0.63) | ALOX5DHODHKMT2AALDH1A1GLA | |
| SCHEMBL9840343 | 0.80 | ALOX5 (0.40) | ALOX5DHODHMAPTTDP1L3MBTL1 | |
| Phenoxazine SCHEMBL28350911 | 0.80 | ALOX5 (0.61) | ALOX5DHODHKMT2AALDH1A1GLA | |
| SCHEMBL31191628 | 0.77 | ALOX5 (0.55) | ALOX5DHODHALDH1A1GLAHPGD | |
| SCHEMBL121074 | 0.77 | ALOX5 (0.55) | ALOX5DHODHALDH1A1GLAHPGD | |
| SCHEMBL30530994 | 0.77 | ALOX5 (0.55) | ALOX5DHODHALDH1A1GLAHPGD | |
| SCHEMBL28571843 | 0.75 | ALOX5 (0.53) | ALOX5DHODHALDH1A1GLAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10654869-B2 | Bacterial topoisomerase I inhibitors with antibacterial activity | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2020-05-19 | — | — | US | disclosed |
| US-20190194224-A1 | BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES | 2019-06-27 | — | — | US | disclosed |
| US-10266550-B2 | Bacterial topoisomerase I inhibitors with antibacterial activity | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2019-04-23 | — | — | US | disclosed |
| US-20180079757-A1 | BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES | 2018-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180079757-A1 | BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY | TOP1, TOP2A, TOP2B | ALOX5 2757/4885DHODH 624/4885KMT2A 2065/4885 |
| US-10654869-B2 | Bacterial topoisomerase I inhibitors with antibacterial activity | TOP1, TOP2A, TOP2B | ALOX5 2757/4885DHODH 624/4885KMT2A 2065/4885 |
| US-10266550-B2 | Bacterial topoisomerase I inhibitors with antibacterial activity | TOP1, TOP2A, TOP2B | ALOX5 2757/4885DHODH 624/4885KMT2A 2065/4885 |
| US-20190194224-A1 | BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY | TOP1, TOP2A, TOP2B | ALOX5 2861/4885DHODH 663/4885KMT2A 2126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.