Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.45 |
| ▸ | DHODH | Q02127 | 1/20 | 0.40 |
| ▸ | C1R | P00736 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PLAUR | Q03405 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19971565 | 0.85 | ALOX5 (0.44) | ALOX5DHODHMAPTTDP1L3MBTL1 | |
| SCHEMBL9838372 | 0.78 | ALOX5 (0.41) | ALOX5DHODHMAPTTDP1L3MBTL1 | |
| SCHEMBL9840343 | 0.77 | ALOX5 (0.40) | ALOX5DHODHMAPTTDP1L3MBTL1 | |
| SCHEMBL19971560 | 0.76 | ALOX5 (0.59) | ALOX5DHODHMAPTTDP1L3MBTL1 | |
| SCHEMBL28780034 | 0.74 | ALOX5 (0.45) | ALOX5DHODHMAPTTDP1L3MBTL1 | |
| Phenoxazine SCHEMBL3961176 | 0.71 | ALOX5 (0.74) | ALOX5DHODHMAPTTDP1L3MBTL1 | |
| SCHEMBL9227117 | 0.71 | ALOX5 (0.47) | ALOX5DHODHMAPTHTTNPSR1 | |
| SCHEMBL121074 | 0.70 | ALOX5 (0.55) | ALOX5DHODHTDP1ALDH1A1NPSR1 | |
| SCHEMBL31191628 | 0.70 | ALOX5 (0.55) | ALOX5DHODHTDP1ALDH1A1NPSR1 | |
| SCHEMBL30530994 | 0.70 | ALOX5 (0.55) | ALOX5DHODHTDP1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10654869-B2 | Bacterial topoisomerase I inhibitors with antibacterial activity | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2020-05-19 | — | — | US | disclosed |
| US-20190194224-A1 | BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES | 2019-06-27 | — | — | US | disclosed |
| US-10266550-B2 | Bacterial topoisomerase I inhibitors with antibacterial activity | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2019-04-23 | — | — | US | disclosed |
| US-20180079757-A1 | BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES | 2018-03-22 | — | — | US | disclosed |
| US-8993607-B2 | Therapeutic compounds | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2015-03-31 | — | — | US | disclosed |
| US-8796300-B2 | Therapeutic compounds | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2014-08-05 | — | — | US | disclosed |
| US-8729060-B2 | Macrocyclic polyoxazole compounds and use thereof | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2014-05-20 | — | — | US | disclosed |
| US-8518928-B2 | Therapeutic compounds | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2013-08-27 | — | — | US | disclosed |
| US-20120238595-A1 | THERAPEUTIC COMPOUNDS | UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY (US) | 2012-09-20 | — | — | US | disclosed |
| EP-2496704-A1 | THERAPEUTIC COMPOUNDS | Rutgers, The State University of New Jersey (US) | 2012-09-12 | — | — | EP | disclosed |
| US-8093235-B2 | Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2012-01-10 | — | — | US | disclosed |
| US-20110230531-A1 | THERAPEUTIC COMPOUNDS | NIH - DEITR | 2011-09-22 | — | — | US | disclosed |
| WO-2011057126-A1 | THERAPEUTIC COMPOUNDS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2011-05-12 | — | — | WO | disclosed |
| EP-2185568-A2 | THERAPEUTIC COMPOUNDS | BOARD OF TRUSTEES, RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2010-05-19 | — | — | EP | disclosed |
| EP-2183256-A1 | THERAPEUTIC COMPOUNDS | Rutgers, The State University of New Jersey (US) | 2010-05-12 | — | — | EP | disclosed |
| EP-2079704-A2 | THERAPEUTIC COMPOUNDS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2009-07-22 | — | — | EP | disclosed |
| US-20090156627-A1 | THERAPEUTIC COMPOUNDS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2009-06-18 | — | — | US | disclosed |
| WO-2009018549-A1 | THERAPEUTIC COMPOUNDS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2009018551-A2 | THERAPEUTIC COMPOUNDS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2009-02-05 | — | — | WO | disclosed |
| WO-2007127173-A2 | THERAPEUTIC COMPOUNDS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2007-11-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120238595-A1 | THERAPEUTIC COMPOUNDS | CCNY, MKI67, MCL1 | ALOX5 3363/4885DHODH 1888/4885C1R 1666/4885 |
| US-20180079757-A1 | BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY | TOP1, TOP2A, TOP2B | ALOX5 2757/4885DHODH 624/4885C1R 4208/4885 |
| US-10654869-B2 | Bacterial topoisomerase I inhibitors with antibacterial activity | TOP1, TOP2A, TOP2B | ALOX5 2757/4885DHODH 624/4885C1R 4208/4885 |
| US-10266550-B2 | Bacterial topoisomerase I inhibitors with antibacterial activity | TOP1, TOP2A, TOP2B | ALOX5 2757/4885DHODH 624/4885C1R 4208/4885 |
| US-20090156627-A1 | THERAPEUTIC COMPOUNDS | TOP2B, DDB1, RECQL | ALOX5 4804/4885DHODH 1374/4885C1R 1433/4885 |
| US-20190194224-A1 | BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY | TOP1, TOP2A, TOP2B | ALOX5 2861/4885DHODH 663/4885C1R 4264/4885 |
| US-20110230531-A1 | THERAPEUTIC COMPOUNDS | MCL1, MKI67, NCL | ALOX5 2913/4885DHODH 2711/4885C1R 2832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.