Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 10/20 | 0.48 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.48 |
| ▸ | TOP1 | P11387 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3691781 | 0.77 | TOP1 (0.75) | TOP2ATOP2BTOP1 | |
| SCHEMBL4567547 | 0.69 | TOP2A (0.66) | TOP2ATOP2BTOP1 | |
| SCHEMBL3267841 | 0.69 | CHRM1 (0.42) | TOP1KDM4ECHRM1LMNAMAOB | |
| SCHEMBL2183758 | 0.68 | MCL1 (0.49) | KDM4ECHRM1LMNA | |
| Hydrochloric Acid SCHEMBL10435583 | 0.68 | CHRM1 (0.41) | TOP1KDM4ECHRM1LMNAMAOB | |
| SCHEMBL27537560 | 0.67 | LMNA (0.51) | KDM4ECHRM1LMNA | |
| Phthalic Acid SCHEMBL28481098 | 0.66 | ALDH1A1 (0.70) | KDM4EP2RX4ALOX5 | |
| SCHEMBL5100563 | 0.66 | KDM4E (0.61) | KDM4ECHRM1LMNA | |
| SCHEMBL30309433 | 0.66 | KDM4E (0.61) | KDM4ECHRM1LMNA | |
| SCHEMBL9559749 | 0.65 | KDM4E (0.44) | KDM4ECHRM1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10654869-B2 | Bacterial topoisomerase I inhibitors with antibacterial activity | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2020-05-19 | — | — | US | disclosed |
| US-20190194224-A1 | BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES | 2019-06-27 | — | — | US | disclosed |
| US-10266550-B2 | Bacterial topoisomerase I inhibitors with antibacterial activity | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES (US) | 2019-04-23 | — | — | US | disclosed |
| US-20180079757-A1 | BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY | THE FLORIDA INTERNATIONAL UNIVERSITY BOARD OF TRUSTEES | 2018-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180079757-A1 | BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY | TOP1, TOP2A, TOP2B | TOP2A 2/4885TOP2B 3/4885TOP1 1/4885 |
| US-10654869-B2 | Bacterial topoisomerase I inhibitors with antibacterial activity | TOP1, TOP2A, TOP2B | TOP2A 2/4885TOP2B 3/4885TOP1 1/4885 |
| US-10266550-B2 | Bacterial topoisomerase I inhibitors with antibacterial activity | TOP1, TOP2A, TOP2B | TOP2A 2/4885TOP2B 3/4885TOP1 1/4885 |
| US-20190194224-A1 | BACTERIAL TOPOISOMERASE I INHIBITORS WITH ANTIBACTERIAL ACTIVITY | TOP1, TOP2A, TOP2B | TOP2A 2/4885TOP2B 3/4885TOP1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.