Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL21485332 | 0.98 | MAOB (0.38) | MAOBMAOASMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL20657839 | 0.86 | MAOB (0.39) | MAOBMAOASMN1; SMN2KMT2AKDM4E | |
| SCHEMBL29875394 | 0.81 | ABL1 (0.45) | KMT2AKDM4EMEN1ALDH1A1PKM | |
| SCHEMBL26918326 | 0.81 | ABL1 (0.45) | KMT2AKDM4EMEN1ALDH1A1PKM | |
| SCHEMBL18412803 | 0.73 | MAOB (0.35) | MAOBMAOASMN1; SMN2KEAP1NFE2L2 | |
| SCHEMBL24659358 | 0.73 | KEAP1 (0.42) | SMN1; SMN2KEAP1NFE2L2KDM4EALDH1A1 | |
| SCHEMBL22246397 | 0.73 | SMN1; SMN2 (0.39) | MAOBMAOASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL20302581 | 0.73 | SMN1; SMN2 (0.44) | MAOBSMN1; SMN2KMT2AKDM4EMEN1 | |
| SCHEMBL2400774 | 0.72 | HTT (0.39) | KMT2AHTT | |
| SCHEMBL25944824 | 0.71 | SMN1; SMN2 (0.45) | MAOBMAOASMN1; SMN2KEAP1NFE2L2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10081617-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-09-25 | — | — | US | disclosed |
| US-20180079743-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180079743-A1 | FACTOR XIa INHIBITORS | F11, F2, TFPI | MAOB 916/4885MAOA 860/4885SMN1; SMN2 4625/4885 |
| US-10081617-B2 | Factor XIa inhibitors | F11, F2, TFPI | MAOB 916/4885MAOA 860/4885SMN1; SMN2 4625/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.