Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | IKBKB | O14920 | 2/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.31 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.30 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20657839 | 0.80 | MAOB (0.39) | SMN1; SMN2MAOBMAOAHSD17B10KDM4E | |
| SCHEMBL22246399 | 0.75 | ALDH1A1 (0.42) | SMN1; SMN2KDM4EALDH1A1GAAHPGD | |
| SCHEMBL20657821 | 0.74 | CLK4 (0.44) | SMN1; SMN2KDM4EALDH1A1GAACDK5 | |
| SCHEMBL19972183 | 0.73 | MAOB (0.39) | SMN1; SMN2MAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL20657823 | 0.73 | ADORA2B (0.40) | IKBKB | |
| Bromide SCHEMBL21485332 | 0.71 | MAOB (0.38) | SMN1; SMN2MAOBMAOAKDM4EALDH1A1 | |
| SCHEMBL22246384 | 0.69 | KMT2A (0.34) | ALDH1A1GAA | |
| SCHEMBL14967159 | 0.68 | KDM4E (0.41) | HSD17B10KDM4EALDH1A1GLAGAA | |
| SCHEMBL11992010 | 0.68 | HTT (0.50) | SMN1; SMN2MAOAHSD17B10KDM4EALDH1A1 | |
| SCHEMBL23689684 | 0.67 | KDM4E (0.42) | HSD17B10KDM4EALDH1A1GLAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020150676-A1 | 1,8-NAPHTHYRIDINONE COMPOUNDS AND USES THEREOF | NUVATION BIO INC. (US) | 2020-07-23 | — | — | WO | disclosed |