Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR1 | P21462 | 7/20 | 0.68 |
| ▸ | FPR2 | P25090 | 2/20 | 0.68 |
| ▸ | HSD17B2 | P37059 | 3/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20001277 | 0.86 | FPR1 (0.63) | FPR1FPR2HSD17B2PDE4BSLC6A2 | |
| SCHEMBL19988380 | 0.86 | FPR1 (0.63) | FPR1FPR2HSD17B2PDE4BSLC6A2 | |
| SCHEMBL19972286 | 0.82 | FPR1 (0.71) | FPR1FPR2 | |
| SCHEMBL19972337 | 0.81 | FPR1 (1.00) | FPR1FPR2 | |
| SCHEMBL19972336 | 0.81 | FPR1 (1.00) | FPR1FPR2 | |
| SCHEMBL19988377 | 0.81 | FPR1 (1.00) | FPR1FPR2 | |
| SCHEMBL19972384 | 0.81 | FPR1 (0.55) | FPR1FPR2L3MBTL1PDE4APDE4B | |
| SCHEMBL19972394 | 0.77 | FPR1 (0.69) | FPR1FPR2 | |
| SCHEMBL21332026 | 0.77 | FPR1 (0.49) | FPR1FPR2L3MBTL1 | |
| SCHEMBL18043489 | 0.77 | EPHX2 (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3515902-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | Grünenthal GmbH (DE) | 2019-07-31 | — | — | EP | disclosed |
| US-10265310-B2 | 6-membered cyclic amines or lactames substituted with urea and phenyl | Grünenthal GmbH (DE) | 2019-04-23 | — | — | US | disclosed |
| WO-2018054549-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | Grünenthal GmbH (DE) | 2018-03-29 | — | — | WO | disclosed |
| US-20180078541-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | Grünenthal GmbH (DE) | 2018-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180078541-A1 | 6-MEMBERED CYCLIC AMINES OR LACTAMES SUBSTITUTED WITH UREA AND PHENYL | FPR2, FPR1, FPR3 | FPR1 2/4885FPR2 1/4885HSD17B2 2352/4885 |
| US-10265310-B2 | 6-membered cyclic amines or lactames substituted with urea and phenyl | FPR2, FPR1, FPR3 | FPR1 2/4885FPR2 1/4885HSD17B2 2352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.