SCHEMBL19973149

SCHEMBL19973149

FC(F)(F)c1cncc(Cl)c1CBr

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP11B1 P15538 2/20 0.34
CYP11B2 P19099 2/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21938381 0.81 CYP11B1 (0.34) CYP11B1CYP11B2
SCHEMBL5999271 0.81 CYP11B1 (0.34) CYP11B1CYP11B2
SCHEMBL843448 0.79 GAA (0.32)
Hydrochloric Acid SCHEMBL6627934 0.77 PDE4D (0.31)
Bromide SCHEMBL844917 0.77 PDE4D (0.31)
SCHEMBL19973145 0.74 KCNQ2 (0.31)
SCHEMBL28380278 0.73 CYP11B2 (0.39) CYP11B1CYP11B2
SCHEMBL31667050 0.71 NOX1 (0.30)
SCHEMBL29393476 0.71 P2RX7 (0.41)
SCHEMBL696040 0.71 P2RX7 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2018052903-A1 RORγ MODULATORS THE SCRIPPS RESEARCH INTITUTE (US) 2018-03-22 WO disclosed