Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.53 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 6/20 | 0.49 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.49 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.49 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.49 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.49 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.49 |
| ▸ | CDK4 | P11802 | 2/20 | 0.46 |
| ▸ | CCND1 | P24385 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 3/20 | 0.42 |
| ▸ | GABRP | O00591 | 3/20 | 0.41 |
| ▸ | GABRD | O14764 | 3/20 | 0.41 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.41 |
| ▸ | GABRE | P78334 | 3/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.41 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.41 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19988566 | 0.95 | MAP3K11 (0.53) | MAP3K11MAP3K9GABRA1GABRG2GABRB3 | |
| SCHEMBL24768761 | 0.89 | GABRA1 (0.49) | MAP3K11MAP3K9GABRA1GABRG2GABRB3 | |
| SCHEMBL29506369 | 0.82 | MAP3K11 (0.59) | MAP3K11MAP3K9GABRA1GABRG2GABRB3 | |
| SCHEMBL17228831 | 0.82 | MAP3K11 (0.59) | MAP3K11MAP3K9GABRA1GABRG2GABRB3 | |
| SCHEMBL30883881 | 0.82 | MAP3K11 (0.59) | MAP3K11MAP3K9GABRA1GABRG2GABRB3 | |
| SCHEMBL18042294 | 0.81 | GABRA1 (0.60) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL19988560 | 0.81 | MAP3K11 (0.47) | MAP3K11MAP3K9GABRA1GABRG2GABRB3 | |
| SCHEMBL21155925 | 0.80 | GABRA1 (0.43) | MAP3K11MAP3K9GABRA1GABRG2GABRB3 | |
| SCHEMBL19988529 | 0.80 | MAP3K11 (0.49) | MAP3K11MAP3K9GABRA1GABRG2GABRB3 | |
| SCHEMBL19988532 | 0.80 | MAP3K11 (0.51) | MAP3K11MAP3K9GABRA1GABRG2GABRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512848-B1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2020-11-18 | — | — | EP | disclosed |
| EP-3512848-B1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2020-11-18 | — | — | EP | disclosed |
| EP-3512848-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | Merck Patent GmbH (DE) | 2019-07-24 | — | — | EP | disclosed |
| US-20190214574-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2019-07-11 | — | — | US | disclosed |
| US-20190214574-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2019-07-11 | — | — | US | disclosed |
| WO-2018050583-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2018-03-22 | — | — | WO | disclosed |
| WO-2018050583-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | MERCK PATENT GMBH (DE) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190214574-A1 | COMPOUNDS WITH CARBAZOLE STRUCTURES | CYCS, CYP3A4, CYP2E1 | MAP3K11 1974/4885MAP3K9 1892/4885GABRA1 1058/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.