SCHEMBL19974348

SCHEMBL19974348

CC(C)(C)OC(=O)C1(c2cc(Cl)cc(CN3CCN(C(=O)O)CC3C(C(F)(F)F)C(F)(F)F)c2)CCCC1

nearest known ligand 0.33

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
STS P08842 1/20 0.30
NR1H2 P55055 1/20 0.30
NR1H3 Q13133 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29170860 0.83 MGLL (0.36)
SCHEMBL29170872 0.78 MGLL (0.39)
SCHEMBL29170868 0.77
SCHEMBL19974449 0.76 MGLL (0.56)
SCHEMBL28303847 0.72 DDR1 (0.40)
SCHEMBL28994342 0.71 MGLL (0.38)
SCHEMBL21082979 0.70 MAPT (0.36) STS
SCHEMBL15094637 0.70 MGLL (0.46)
SCHEMBL29170873 0.70 MGLL (0.36)
SCHEMBL29170864 0.68 MGLL (0.43)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109996790-B Piperazine carbamates and methods of making and using the same H.隆德贝克有限公司 2023-05-16 CN disclosed
EP-3515897-A1 PIPERAZINE CARBAMATES AND METHODS OF MAKING AND USING SAME Abide Therapeutics, Inc. (US) 2019-07-31 EP disclosed
WO-2018053447-A1 PIPERAZINE CARBAMATES AND METHODS OF MAKING AND USING SAME ABIDE THERAPEUTICS, INC. (US) 2018-03-22 WO disclosed