Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MME | P08473 | 1/20 | 0.32 |
| ▸ | ACE | P12821 | 2/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13101906 | 1.00 | ATM (0.53) | ATMGAAMMEACESCN9A | |
| SCHEMBL30438193 | 1.00 | ATM (0.53) | ATMGAAMMEACESCN9A | |
| SCHEMBL28311654 | 1.00 | ATM (0.53) | ATMGAAMMEACESCN9A | |
| SCHEMBL28210183 | 0.80 | ATM (0.42) | ATMGAA | |
| SCHEMBL27925973 | 0.77 | ATM (0.35) | ATM | |
| SCHEMBL28153658 | 0.76 | ATM (0.57) | ATMGAAMMEACE | |
| SCHEMBL27678902 | 0.74 | ATM (0.55) | ATMGAAMMEACESCN9A | |
| SCHEMBL6678799 | 0.73 | ATM (0.53) | ATMGAAMMEACE | |
| SCHEMBL6819415 | 0.73 | ATM (0.53) | ATMGAAMMEACESCN9A | |
| SCHEMBL1249542 | 0.73 | ATM (0.70) | ATMGAAMMEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250129125-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2025-04-24 | — | — | US | claimed |
| US-12187816-B2 | Macrocyclic compounds and methods of use thereof | GENENTECH, INC. (US) | 2025-01-07 | — | — | US | claimed |
| EP-4168121-A2 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2023-04-26 | — | — | EP | claimed |
| CN-115702026-A | Macrocyclic compounds and methods of use thereof | 基因泰克公司 | 2023-02-14 | — | — | CN | claimed |
| US-20220106361-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2022-04-07 | — | — | US | claimed |
| US-20250129125-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2025-04-24 | — | — | US | disclosed |
| US-12187816-B2 | Macrocyclic compounds and methods of use thereof | GENENTECH, INC. (US) | 2025-01-07 | — | — | US | disclosed |
| EP-4168121-A2 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2023-04-26 | — | — | EP | disclosed |
| CN-109952299-B | Fluorohydroxyproline derivatives for the preparation of protein degradation targeting chimeras | 邓迪大学 | 2023-04-18 | — | — | CN | disclosed |
| CN-109952299-B | Fluorohydroxyproline derivatives for the preparation of protein degradation targeting chimeras | 邓迪大学 | 2023-04-18 | — | — | CN | disclosed |
| CN-115702026-A | Macrocyclic compounds and methods of use thereof | 基因泰克公司 | 2023-02-14 | — | — | CN | disclosed |
| CN-109678852-B | 6-oxo-hexahydropyrimidine derivative, preparation method and pharmaceutical application thereof | 南京中医药大学 | 2022-04-19 | — | — | CN | disclosed |
| US-20190255066-A1 | FLUOROHYDROXYPROLINE DERIVATIVES USEFUL IN THE PREPARATION OF PROTEOLYSIS TARGETED CHIMERAS | UNIVERSITY OF DUNDEE (GB) | 2019-08-22 | — | — | US | disclosed |
| EP-3512844-A1 | FLUOROHYDROXYPROLINE DERIVATIVES USEFUL IN THE PREPARATION OF PROTEOLYSIS TARGETED CHIMERAS | University Of Dundee (GB) | 2019-07-24 | — | — | EP | disclosed |
| EP-3512844-A1 | FLUOROHYDROXYPROLINE DERIVATIVES USEFUL IN THE PREPARATION OF PROTEOLYSIS TARGETED CHIMERAS | University Of Dundee (GB) | 2019-07-24 | — | — | EP | disclosed |
| CN-109952299-A | Fluorohydroxyproline derivatives for preparing protein degradation targeting chimeras | 邓迪大学 | 2019-06-28 | — | — | CN | disclosed |
| CN-109952299-A | Fluorohydroxyproline derivatives for preparing protein degradation targeting chimeras | 邓迪大学 | 2019-06-28 | — | — | CN | disclosed |
| CN-109952299-A | Fluorohydroxyproline derivatives for preparing protein degradation targeting chimeras | 邓迪大学 | 2019-06-28 | — | — | CN | disclosed |
| WO-2018051107-A1 | FLUOROHYDROXYPROLINE DERIVATIVES USEFUL IN THE PREPARATION OF PROTEOLYSIS TARGETED CHIMERAS | UNIVERSITY OF DUNDEE (GB) | 2018-03-22 | — | — | WO | disclosed |
| WO-2018051107-A1 | FLUOROHYDROXYPROLINE DERIVATIVES USEFUL IN THE PREPARATION OF PROTEOLYSIS TARGETED CHIMERAS | UNIVERSITY OF DUNDEE (GB) | 2018-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220106361-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | PAICS, CYCS, LSS | ATM 2729/4885GAA 1370/4885MME 1796/4885 |
| US-12187816-B2 | Macrocyclic compounds and methods of use thereof | PAICS, CYCS, LSS | ATM 2729/4885GAA 1370/4885MME 1796/4885 |
| US-20250129125-A1 | MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF | PAICS, CYCS, LSS | ATM 2729/4885GAA 1370/4885MME 1796/4885 |
| US-20190255066-A1 | FLUOROHYDROXYPROLINE DERIVATIVES USEFUL IN THE PREPARATION OF PROTEOLYSIS TARGETED CHIMERAS | RNF114, CUL1, MDM2 | ATM 4350/4885GAA 2255/4885MME 587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.